• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
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    • 专利摘要:
    Autoinjector comprising: - a body (1) receiving a reservoir (S), said reservoir (S) containing fluid and comprising a piston (P), such as a pre-filled syringe, - a piston rod (5) adapted to cooperate with the piston (P) of said reservoir (S), said piston rod (5) being displaceable by an injection spring (8) between a loaded position and an injection position in which said piston rod ( 5) has moved the piston (P) of the reservoir (S) to inject the fluid product in an injection site, - an indicating device to indicate to the user that it can remove said autoinjector said injection site, said autoinjector comprising a delaying system for delaying the end of actuation of said indicator device with respect to the end of the injection, said indicator device generating a noise during its actuation, said noise being generated until the end of actuation of said indicator device .
    公开号:FR3036967A1
    申请号:FR1555166
    申请日:2015-06-05
    公开日:2016-12-09
    发明作者:David Fabien；Thomas Gomez；Anthony Saussaye；Philippe Pinheiro
    申请人:Aptar France SAS；
    IPC主号:
    专利说明:

    [0001] The present invention relates to an autoinjector. Auto-injectors are well known in the state of the art. These devices are primarily intended to achieve an automatic injection of the contents of a syringe inside the body of a patient. Various systems exist to make automatic the penetration of the needle into the patient's body as well as the injection of the fluid contained in the syringe. Auto-injectors are relatively complex devices that must meet a number of constraint requirements to be reliable. The robustness of the device, its maneuverability, and its ease of use for the user are also important elements. Moreover, most of these autoinjectors are single-use, the cost of manufacturing and assembly is also a factor to consider. There are many autoinjectors on the market, but they have a number of disadvantages.
    [0002] Thus, especially when the volume of fluid product is relatively large and / or when the fluid injected is relatively viscous, it is desirable to allow the product to diffuse from the injection site for a few seconds after said injection. If the user removes the autoinjector immediately after the end of the injection, part of the product can emerge from the body of the user which decreases the effectiveness of the treatment. It is therefore desirable to provide that the user maintains the autoinjector against his body for a few seconds after the end of the injection. This aspect is generally solved by the existing autoinjectors by the user manual which requires the user to count in his head a number of seconds before removing the device. This is not reliable and therefore unsatisfactory, because the system then depends on the user himself, which in some cases may be disrupted or weakened by the injection action he has just made. The present invention aims to provide an autoinjector which does not reproduce the aforementioned drawbacks, and which makes it possible to meet the various requirements and constraints important for safe and reliable use of the autoinjector.
    [0003] The present invention also aims to provide a self-injector that is reliable in use, which allows the user to determine when to remove or when he can remove the autoinjector from his body after use, which is safe and which prevents any risk of injury, and which is simple and inexpensive to manufacture and assemble. The present invention therefore relates to an autoinjector comprising: - a body receiving a reservoir, said reservoir containing fluid and comprising a piston, such as a pre-filled syringe, - a piston rod adapted to cooperate with the piston of said reservoir, said piston rod being movable by an injection spring between a loaded position and an injection position in which said piston rod has moved the piston of the reservoir to inject the fluid into an injection site; an indicating device for indicating to the user that he can withdraw said autoinjector from said injection site, said autoinjector comprising a delaying system for delaying the end of actuation of said indicator device with respect to the end of the injection, said indicator device generating a noise during its actuation, said noise being generated until the end of actuation of said indicator device.
    [0004] Advantageously, said indicating device and / or said delaying system comprises a rotatable member adapted to cooperate with said body to generate said noise. According to a first advantageous embodiment, said indicator device comprises a hood, the body, an indicator strip, an indicator spring, a driving wheel, a winding wheel and a unwinding wheel. Advantageously, said indicator spring is in the form of a spiral spring fixed on the one hand to said drive wheel and on the other hand to said body.
    [0005] Advantageously, said driving wheel comprises a gear which cooperates with a gear of the winding wheel, so that rotation of said driving wheel causes rotation of said winding wheel, which causes winding of the winding wheel. said indicator strip on said winding wheel. Advantageously, said locking key comprises a head, a longitudinal rod, and tip adapted to cooperate with the piston rod.
    [0006] Advantageously, before triggering of the indicator device, the head of the locking key is in the locking position in which it cooperates with a corresponding profile of the drive wheel, so that said drive wheel is locked in rotation relative to said body and said hood by said lock key.
    [0007] Advantageously, when the piston rod reaches its end of injection position, it cooperates with the end of the locking key to pull said locking key axially down out of its locking position, so that said driving wheel is no longer locked in rotation by said locking key.
    [0008] Advantageously, said body comprises at least one flexible tab adapted to cooperate with said drive wheel to generate a noise during the rotation of said driving wheel. According to a second advantageous embodiment, said retarding system comprises an epicyclic gear train having at least one, advantageously two, stage (s), said epicyclic gear train comprising a retarding spring, at least one sun gear, each comprising at least one satellite, a trigger, and a locking key for locking said trigger in rotation until the end of injection. Advantageously, said retarding spring is in the form of a spiral spring fixed on the one hand to a sun gear or trigger and on the other hand to the body. Advantageously, each planet of a sun gear cooperates on the one hand with said body and on the other hand with another sun gear, or with said trigger.
    [0009] Advantageously, said body comprises a gear on its lateral internal surface, said gear co-operating with at least one satellite.
    [0010] Advantageously, said trigger comprises a central axis provided with a gear cooperating with at least one satellite. Advantageously, said epicyclic train comprises two planetaries, each comprising three satellites.
    [0011] Advantageously, said locking key comprises a head, a longitudinal rod, and tip adapted to cooperate with the piston rod. Advantageously, before triggering the delaying system, the head of the locking key is in the locking position in which it cooperates with a corresponding profile of the body and with a corresponding profile of the trigger, so that said trigger is locked in rotation relative to said body by said locking key. Advantageously, when the piston rod reaches its end-of-injection position, it cooperates with the end of the locking key to pull said locking key axially down out of its locking position, so that said trigger is no longer locked in rotation by said locking key. Advantageously, said trigger comprises at least one flexible tab adapted to cooperate with said body to generate a noise during the rotation of said trigger.
    [0012] According to a third advantageous embodiment, said retarding system comprises a reservoir, a shearing member disposed in said reservoir and a fluid disposed in said reservoir around said shearing member, one of said reservoir and said shearing member being mounted rotating in said body and the other of said reservoir and said shear member being fixed in rotation, the rotation of one with respect to the other being braked by shearing said fluid contained in said reservoir. Advantageously, said tank is rotatably mounted in said body and said shear member is fixed in rotation. Advantageously, said reservoir has projections on its inner surface and said shear member has projections on its outer surface, said projections generating restrictions on the flow of the fluid.
    [0013] Advantageously, said delaying system comprises said reservoir containing said fluid, said shearing member, a delaying spring, a locking key and said piston rod. Advantageously, said locking key comprises a head, a longitudinal rod and endpiece adapted to cooperate with the piston rod. Advantageously, before the self-timer system is triggered, the head of the locking key is in the locking position in which it cooperates with a corresponding profile of the body and with a corresponding profile of said reservoir, so that said reservoir is blocked in rotation relative to said body by said locking key. Advantageously, when the piston rod reaches its end of injection position, it cooperates with the end of the locking key to pull said locking key axially down out of its locking position, so that said reservoir is then no longer locked in rotation by said locking key. Advantageously, said delaying spring is in the form of a spiral spring fixed on the one hand to said reservoir or to said shearing member and on the other hand to said body. Advantageously, said reservoir comprises at least one flexible tab 20 cooperating with a plurality of profiles of said body, to generate a continuous noise during the actuation of said delay system. Advantageously, said autoinjector comprises an actuator sleeve having a contact end intended to come into contact with the body of the user, said actuator sleeve extending at least partially inside said body and being movable relative to said body between projected positions, wherein said actuator sleeve at least partially protrudes from said body, and an actuating position, wherein said actuator sleeve is axially displaced inwardly of said body, said actuator sleeve being in a first projected position before actuating the autoinjector and in a second projected position after actuating the autoinjector.
    [0014] Advantageously, said reservoir comprises a needle through which said fluid product is injected into said injection site. Advantageously, one of said rotatable member and said body comprises at least one flexible tab cooperating with adapted profiles formed on the other of said rotatable member and said body for generating said noise. Advantageously, the shapes and / or dimensions of said at least one flexible tab and / or said adapted profiles are variable, to generate a variable noise.
    [0015] These and other features and advantages of the present invention will become more apparent from the following detailed description, with reference to the accompanying drawings, given as non-limiting examples, and in which: FIGS. 1a and 1b are schematic views, respectively of side and in cross-section, of an autoinjector according to a first advantageous embodiment of the present invention, in position after stitching and before injection, FIGS. 2a and 2b are views similar to those of FIGS. 1a and 1b, after injection and during actuation of the indicator device, FIGS. 3a and 3b are views similar to those of FIGS. 2a and 2b, at the end of actuation of the indicator device. FIG. similar to that of FIG. 3a, in end-of-use position, after withdrawal of the autoinjector from the injection site. FIG. 5 is an exploded perspective view of a part of 2 The autoinjector according to said first embodiment of FIGS. 1 to 4; FIG. 6 is an exploded perspective view of the indicator device according to said first embodiment of FIGS. 1 to 5; FIGS. 7 and 8 are perspective views. FIGS. 9 and 10 are detailed perspective views of the operation of the indicator device of FIG. 6, viewed from above, 3036967 7 FIG. 11 is a diagrammatic cross-sectional detail view of a portion of the autoinjector of FIGS. 1 to 5, showing more particularly the indicating device of FIG. 6, in the position of FIG. 1 b, FIGS. 12d are diagrammatic cross-sectional views respectively along the sectional planes AA, BB, CC and DD of FIG. 11, FIGS. 13a and 13b are diagrammatic views, respectively of side and s cross section, of an autoinjector according to a second advantageous embodiment of the present invention, in position after injection and at the beginning of actuation of the retarding system. FIG. 14 is an exploded perspective view of the retarding system according to said second embodiment. FIG. 15 is a diagrammatic cross-sectional detail view of a portion of the autoinjector of FIGS. 13 and 14, showing more particularly the delay system. FIGS. 16a to 16d are views. schematic in cross-section, respectively according to the sectional planes AA, BB, CC and DD of FIG. 15, FIG. 17 is a schematic cross-sectional view along the section plane EE of FIG. 15, illustrating an embodiment variant. FIGS. 18a and 18b are perspective detail views of another embodiment, FIG. 19 is a perspective detail view of still another embodiment. FIGS. 20a and 20b are diagrammatic views, respectively of side and in cross-section, of an autoinjector according to a third advantageous embodiment of the present invention, in position after injection and at the beginning of FIG. 21 is an exploded perspective view of the retarder system according to said second embodiment of FIGS. 20a and 20b; FIG. 22 is a schematic cross-sectional detail view of a part of the FIG. 20 and 21, more particularly showing the retarder system, and FIGS. 23a to 23c are diagrammatic cross-sectional views, respectively along the sectional planes AA, BB and CC of FIG. 22. In the description below, FIGS. after, the terms "upper", "lower", "high" and "low" refer to the positions shown in Figures 1a to 4, 11, 13a, 13b, 15, 20a, 20b and 22. The "Axial" and "radial" terms refer to the longitudinal central axis X, shown in particular in Figures 1a, 13a and 20a, which corresponds to the longitudinal axis of the needle. The autoinjector will be described hereinafter with reference to three advantageous embodiments thereof. It should be noted, however, that autoinjectors, which are complex devices, include several modules to perform several functions. These various modules can be used separately and independently of each other, without necessarily being combined with other modules, and could in particular be used in autoinjectors of different shape from that shown in the drawings. In addition, it should be noted that the drawings are schematic views which do not necessarily represent the exact form of the components of an autoinjector, and are not necessarily to scale, especially for purposes of clarity. Furthermore, the drawings do not necessarily represent all the constituent elements of an autoinjector, but only the elements necessary for the operation of the present invention. Thus, various additional and / or complementary elements and modules could be associated with the autoinjector shown in the figures. The autoinjector shown in the figures comprises a body 1 in which slides axially an actuator sleeve 10, the lower end 101 is intended to come into contact with the body of the patient around the injection zone. In the examples, the autoinjector comprises a lower body 1a, an intermediate body 1b and an upper body 1c which are assembled to form the body 1 of the autoinjector. Hereinafter, the term "body" and numeral "1" will be used to designate said unitary body formed by the assembly of said lower body 1a with said intermediate body 1b and said upper body 1c. It should be noted that the body 1 5 could be formed of any number of body parts, and that the embodiments of the figures, with three body parts, are not limiting. A tank S can be inserted into said autoinjector. This reservoir S contains fluid, and comprises a piston P and a needle A. The piston 10 P is adapted to move in said reservoir S to inject the fluid through said needle A. Optionally, the present invention could also s to apply to a tank without a needle, especially in a needle-less injection device. The present description will be made with reference to a syringe S, which may be of any type. More generally, it is understood that the term "syringe" in the present description encompasses any type of reservoir associated with a needle. Preferably, the reservoir S is a pre-filled syringe. Before actuating the autoinjector, the needle A of the syringe S 20 may be protected by a cap (not shown), the autoinjector may include a cap (not shown) that the user can remove before operation. The removal of the cover advantageously causes the removal of the cap. Before actuation, the actuator sleeve 10 is in a first projected position in which it surrounds the needle A. On actuation, the actuator sleeve 10 slides inside the body 1 to an actuating position, to expose the needle A and allow the stitching and then the injection of the fluid product. Figure 1b illustrates the autoinjector after stitching but before injection. Figures 2b, 3b, 13b and 20b illustrate the autoinjector after injection. After the injection, when the user withdraws the autoinjector from the injection site, the actuator sleeve 10 returns to a second end-of-use position, in which it is again placed around the A-needle. , to avoid any risk of injury with said needle, as shown in Figure 4. The actuator sleeve 10 is advantageously biased towards its 5 projected positions by an elastic member or spring 190, which can be of any type. Advantageously, in said position of end of use, said actuator sleeve 10 is locked, and can no longer be moved axially inwardly of said body 1. This locking can for example be achieved by tabs (not shown), integral with the body 1 or tank S, and cooperating with openings (not shown) of said actuator sleeve 10 when it reaches its second projected position. This locking, which is not essential to the operation of the present invention, will not be described in more detail hereinafter. It could be realized differently from the particular embodiment mentioned above. In particular, it could be realized in accordance with the teachings of WO2013175140 or WO2013175142. The autoinjector also comprises an automatic injection system, including in particular a piston rod 5 adapted to cooperate with the piston P to move it in the tank S to dispense the fluid product through the needle A. This piston rod 5 is conventionally solicited by an injection spring 8 to its dispensing position, and retained before actuation in its rest position by a suitable injection lock. The injection spring 8 is shown only for the first and second embodiments.
    [0016] An advantageous injection lock is in particular described in document PCT / FR2015 / 050940, which is a co-pending application. The lock may comprise at least one locking element (not shown) retained in the locking position by a fixed locking ring 230, in particular snapped onto a support member 6 on which the injection spring 8 rests. of said injection lock causes the actuation of said injection means and therefore the injection of the fluid product through the needle. Said injection lock may further comprise a control sleeve 4 disposed in said body 1, said control sleeve 4 containing said piston rod 5 and said injection spring 8, said piston rod 5 having a radial recess receiving at least one movable locking element between a locking position and an unlocking position. Said at least one blocking element is preferably of substantially spherical shape, such as a ball. Advantageously, said balls are biased radially outwardly by said piston rod 5 and are retained in the blocking position by the locking ring 230. This locking ring 230 is axially displaceable with respect to said piston rod 5 and by report to said support member 6 between a locking position, in which it holds said balls in the locked position, and an unlocking position, wherein said balls are released to thereby unlock said injection lock, allowing said injection spring 8 moving said piston rod 5 towards its injection position. The locking ring 230 can in particular be moved to its unlocking position by said control sleeve 4. When the needle A of the syringe S has penetrated the body of the user, the locking ring 230 is moved axially towards the high, which has the effect of releasing the balls from their locking position, these being then moved radially outwards. The piston rod 5 is then no longer retained by the balls and is thus moved axially downwards to achieve the injection of the product. The autoinjector includes an indicating device for indicating to the user, particularly by audible sound, vibration and / or visual and / or tactile indication, that he / she can remove the autoinjector from the injection site. In particular, the present invention provides for generating a noise during the actuation of the indicator device, the end of said noise signifying the end of actuation of the indicator device. Advantageously in the examples shown, the indicator device further comprises an indicator element which gives a visual indication, by a display 160 in one or more window (s) 11 of the body 1. Advantageously a tactile indication may also be provided.
    [0017] Figures 1 to 12 illustrate an indicating device according to a first advantageous embodiment, Figures 13 to 19 illustrate a second advantageous embodiment, and Figures 20 to 23 illustrate a third advantageous embodiment.
    [0018] In order to prevent the user from withdrawing the autoinjector from the injection site at the end of the injection, the autoinjector comprises a delaying system, which will delay the end of actuation of said indicator device with respect to the end of the injection. 'injection. The indicator system is primarily intended to generate an audible indication for a predetermined time after the end of the fluid injection into the interior of the body. This time allows in particular a diffusion for a few seconds of the product after its injection. Such an indicator also provides a benefit for the user, who no longer has to count, for example up to 10, after its injection, the time taken for this count can be very variable from one user to another. With an indicating device associated with a self-timer system, it facilitates the sequence of use of an autoinjector. Advantageously, the indicating device and / or the delaying system comprises an element that is rotatable relative to the body, the continuous sound being generated during this rotation, for example by means of one or more flexible tabs formed on said movable element, or on said body, and cooperating with adapted profiles formed on the other of said movable member and said body. Advantageously, it is conceivable to modulate the sound produced by said tabs on said adapted profiles, for example: by adjusting the shapes and / or the dimensions of the profiles, and / or by using at least two tabs having different geometries. Thus, the sound produced could for example: - go from a bass sound at the beginning to more at an acute sound at the end, or conversely, and / or - be multi-tone, and / or - have a changing intensity during the delay.
    [0019] The first embodiment of Figs. 1-12 uses a VHS-type flexible tape to generate a continuous audible indication, as well as advantageously a corresponding visual indication. Alternatively, the flexible band could be replaced by a wire or the like.
    [0020] FIG. 5 illustrates a schematic exploded perspective view of the portion of the autoinjector incorporating this indicator system according to the first embodiment. This comprises an indicator module, a locking key 20, the injection spring 8, the piston rod 5, the support member 6 and the intermediate body 1b.
    [0021] FIG. 6 illustrates a schematic perspective exploded view of the indicator module of FIG. 5. This comprises a cover 1000, the upper body 1c, an indicator strip 160, an indicator spring 18, preferably made in the form of a spiral spring, a driving wheel 19, a winding wheel 17a and a unwinding wheel 17b.
    [0022] The driving wheel 19 has a gear 195 which cooperates with a gear 175 of the winding wheel 17a. The unwinding wheel 17b is advantageously freely rotatable under the effect of the traction exerted on it by the indicator band 160 when it is wound on said winding wheel 17a.
    [0023] The spiral spring 18 is fixed on the one hand to the cover 1000, in particular on a central axial projection 1001 thereof, and on the other hand to the drive wheel 19, as can be seen in particular in FIGS. 10 and 12a. The indicator strip 160 is wound on said unwinding wheel 17b, then extends through a first slot 1601 of the upper body 1c to circumnavigate said upper body 1c and pass through a second slot 1602 to finally wind on said winding wheel 17a. The locking key 20 has a head 21 adapted to cooperate with the indicator module, a longitudinal rod 22, and endpiece 23 adapted to cooperate with the piston rod 5.
    [0024] In the position before triggering of the indicator system, the head 21 of the locking key 20 is in the locking position in which it cooperates with a corresponding profile 190 of the driving wheel 19, so that it is locked in rotation. by said key. When the piston rod 5 reaches its end of injection position, it will cooperate with the end piece 23 of the locking key 20, and thus pull said key 20 axially downwards. As a result, the head 21 of said locking key 20 extends axially from said profile 190 of the drive wheel 19, so that said drive wheel 19 is no longer locked in rotation by said key 20. The coil spring 18 requests the driving wheel 19 rotating. As long as the driving wheel 19 is blocked by said locking key 20, the indicator device is thus also blocked.
    [0025] When the indicator device is triggered, the spring 18 rotates the driving wheel 19. This causes the winding wheel 17a to rotate, which will wind the band 160, which will simultaneously unroll it from the unrolling wheel 17b. During the rotation of the driving wheel 19, at least one flexible lug 1100 of the body 1, in particular of the upper body 1c, cooperates with the gear 195 of the driving wheel 19 to generate a continuous sound. Alternatively, this flexible lug 1100 could also cooperate with another part of the driving wheel 19, or the driving wheel 19 could incorporate one or more flexible lugs cooperating with the profiles of the body 1. When the driving wheel 19 stops turn, the sound also stops, and the user knows that he can remove the autoinjector from the injection site. Advantageously, the band 160 comprises markings, for example colored areas and / or signs or symbols, for example numbers, letters, or any other type of marking, to visually inform the user. In FIGS. 1a, 2a, 3a and 4a, this marking has been represented by an X, but this is only an example to illustrate the displacement of the band 160 during the actuation of the indicator device. These markings are visible to the user on the outer portion of the upper body 1c on which said indicator band 160 extends between said first and second slots 1601, 1602. Optionally, the upper body could further comprise one or more windows. for example displaying the end of use visually in addition to the sound information provided by the end of said continuous noise. In a variant, the band could comprise one or more holes or cutouts making it possible to display one or more markings made on the body 1, before, during and / or after winding of said band.
    [0026] The indication duration and / or the delay of the end of indication with respect to the end of the injection can therefore be predetermined by adjusting the parameters of the indicating device, and in particular the length of the indicator band 160, the dimensions gears 195, 175 of the driving wheels 19 and winding 17a, the characteristics of the indicator spring 18, etc.
    [0027] The second embodiment of FIGS. 13 to 19 uses an epicyclic gear train to generate said delay between the end of actuation of the indicator device and the end of the injection. FIG. 14 illustrates a schematic exploded perspective view of this delaying system according to the second embodiment. This comprises the upper body 1c, a retarding spring 18, preferably in the form of a spiral spring, at least one sun gear 16a, 16b, each with at least one satellite 17a ', 17b', a trigger 19 ', a locking key 20, the piston rod 5 and the intermediate body 1b. Each sun gear 16a, 16b associated with its satellites 17a ', 17b' forms a stage of the retarding system. In the example shown in FIGS. 13 to 19, there are two axially stacked stages, with a first sun gear 16a and a second sun gear 16b, but any number of stages, for example a single or more stage, can be provided. two floors. The spiral spring 18 is fixed on the one hand to the first sun gear 16a and on the other hand to the upper body 1c, as shown in FIG. 16a. Alternatively, said spiral spring could be fixed to another sun gear, for example the second sun gear 16b in the example shown, or the trigger 19 '. In addition, the spiral spring could be attached to another part of the body 1, for example the intermediate body 1b, or to any element 30 fixed to said body 1. In the example shown, the first sun gear 16a also forms an element visual indication of the indicating device. Alternatively, this indicator element could be formed by another sun gear, for example the second sun gear 16b in the example shown, or by the trigger. Each sun gear 16a, 16b has a disk-shaped portion on which are formed on one side one or more satellite support rods 161a, 161b which each receive a satellite 17a ', 17b' rotatively. In the example shown, there are three satellites 17a ', 17b' on each floor, so that there are three rods 161a, 161b on each sun gear 16a, 16b. Any number of satellites, however, is possible. The second sun gear 16b has on the axial side opposite the support rods 161b, a central axis 162 provided with a gear, and cooperating with the satellites 17a 'of the first sun gear 16a. Thus, the delay system uses the principle of epicyclic gear trains. Each stage of this system makes it possible to multiply and / or slow down the rotations of the previous stage.
    [0028] The locking key 20 comprises a head 21 adapted to cooperate with the retarding system, a longitudinal rod 22, and endpiece 23 adapted to cooperate with the piston rod 5. In position before triggering the delay system, the head 21 of the locking key 20 is in the locking position in which it cooperates with a corresponding profile 12 of the intermediate body 1b and with a corresponding profile 190 'of the trigger 19', so that it is locked in rotation by said key. When the piston rod 5 reaches its end of injection position, it will cooperate with the end piece 23 of the locking key 20, and thus pull said key axially downwards. Therefore, the head 21 of said locking key 20 extends axially from said profile 190 'of the trigger 19', so that said trigger 19 'is no longer locked in rotation by said key 20. On the opposite axial side to said profile 190 ', the trigger comprises a central axis 192 provided with a gear, and cooperating with the satellites 17b' of the second sun gear 16b. If there were only one stage instead of the two shown, there would not be the second sun gear 16b, and it would be the satellites 17a 'of the first sun 16a which would cooperate directly with the central axis. 192 of the trigger 19 '. Similarly, if there were more than two stages, it would have at least one additional sun gear between the second sun gear 16b and the trigger 19 '.
    [0029] The upper body 1c has a gear 155 on its lateral inner surface, as clearly visible in Figures 16b and 16c. This internal gear 155 of the upper body 1c cooperates with the satellites 17a ', 17b' which are assembled on the planetaries 16a, 16b. The coil spring 18 urges the first sun gear to rotate in the direction of arrow F in Fig. 16a. This rotation is transmitted via the satellites 17a 'to the central axis 162 of the second sun gear 16b, and from there via the satellites 17b' to the central axis 192 of the trigger 19. As long as the trigger 19 'is blocked by said key 20, the delay system is thus also blocked.
    [0030] When the self-timer system is triggered, the spring 18 biases the first sun gear 16a in rotation. The satellites 17a 'are therefore rotated because they are in mesh with the gear 155 of the upper body 1c. This rotation of the satellites 17a 'thus rotates the central axis 162 of the second sun gear 16b, and the same operation is repeated with said second sun gear 16b. The rotational speed of the first sun gear 16a is therefore lower than that of said second sun gear 16b. Each additional stage of the epicyclic gear train forming the retarder will further multiply these rotations, and thus further slow down the rotation of the first sun gear 16a. Thus, with two stages as shown in the figures, it is possible to reduce the rotation of the first sun gear 16a to a single turn while the trigger 19 'will simultaneously perform about twenty turns. Depending on the number of stages and / or on the number of satellites and / or on the shape of the planet gears and / or on the dimensions of the gears involved, the time between the moment when the self-timer system is triggered can be set fairly precisely. at the end of the injection, and the moment when the first sun gear 16a will have realized its predefined rotation to carry out the indication, and in particular indicate in the window of the indicator that the autoinjector can be removed from the injection site. . The end of actuation of the indicator device is delayed with respect to the end of the injection, which allows the injected product to diffuse into the injection site during this delay period.
    [0031] The speed ratio can vary greatly, i.e., the system can be used to slow the first sun gear 16a (gear ratio greater than 1) or to slow the trigger 19 '(gear ratio less than 1). ), for example if it is the trigger that forms the indicator element of the indicator device.
    [0032] In variants with the gear satellites cooperating with the gear 155 of the upper body 1c, it is also possible to envisage a different transmission, for example by friction. According to the invention, means are provided for generating a noise during the actuation period of said delaying system.
    [0033] Figure 17 illustrates a trigger 19 'having three flexible tabs 195a which slide on the gear 155 of the upper body 1c, to generate a continuous noise during the rotation of said trigger 19'. This provides an audible indication of the operation of the self-timer system: when the noise stops, the actuation of the self-timer system is completed, and the user can remove the autoinjector from the injection site. Friction braking can also be provided by these flexible tabs 195a. FIGS. 18a and 18b illustrate another variant, in which the trigger 19 'comprises two flexible tabs 195b, with the ends of these tabs generating a noise during the entire rotation of said trigger 19', for example on an appropriate profile of the upper body . Of course, these tabs 195b can simultaneously provide a braking rotation. Figure 19 shows yet another variant, in which the trigger 19 'includes a single flexible tab 195c, which generates noise during rotation, and which can also slow this rotation. In this variant, the trigger 19 'may include a mass of inertia 196, which promotes braking.
    [0034] It is understood that the one or more flexible lugs 195a, 195b, 195c described above could also be applied to a sun gear 16a, 16b rather than the trigger 19 '. The third embodiment of FIGS. 20 to 23 uses the fluid shear phenomenon to generate said delay between the end of actuation of the indicator device and the end of the injection, and uses a reservoir 16 ', a shear member 19 "disposed in said reservoir 16 ', and a fluid disposed in said reservoir 16', around said shear member 19".
    [0035] In the example shown, the shear member 19 "is fixed in rotation relative to the body 1, and the reservoir 16 'is rotatable relative to said body 1. The reverse is however also possible. disposed in said reservoir 16 ', around said shear member 19 ". Advantageously, the reservoir 16 'has projections 165 on its inner surface and the shear member 19 "has projections 195 on its external surface, which projections 165, 195 generate restrictions on the flow of the fluid. reservoir 16 'with respect to said shear member 19 "therefore involves shearing of the fluid, in particular when a projection 165 of the tank 16' is facing a projection 195 of the shearing member 19", as visible on FIG. The term "fluid shear" is a dynamic viscosity phenomenon Dynamic viscosity corresponds to the shear stress that accompanies the existence of a flow velocity gradient in the material. the capacity of the fluid to flow decreases and the boundary layer phenomenon, which is related to the dynamic viscosity, is exploited.The boundary layer is the interface zone between a rps and the surrounding fluid during a relative movement between the two, as a result of its viscosity. When a fluid flows along a supposedly fixed wall, the velocities on the wall are zero whereas at infinity (that is to say, far from the obstacle) they are equal to the velocity of the disturbed non-3036967 flow. The law of variation depends on the viscosity of the fluid which induces a friction between the adjacent layers: the slowest layer tends to brake the fastest layer which, in return, tends to accelerate it. Under these conditions, a high viscosity equalizes the maximum speeds. On the contrary, if the fluid is not very viscous, the different layers are much more independent: the speed at infinity is maintained until a short distance from the obstacle and there is a greater variation of the speeds in the small thickness of the boundary layer. Depending on the viscosity of the fluid contained in the tank 16 'and / or the shape and / or the dimensions of the profiles 165, 195 of the tank 16' and the shear member 19 ", the braking and therefore the time between the moment when the self-timer system is triggered, at the end of the injection, and the moment when the reservoir 16 'will have realized its predefined rotation to realize the audible and visual indication, and in particular generate a continuous noise during its rotation and indicate at the end of rotation in the window of the indicator that the autoinjector can be removed from the injection site.The end of actuation of the indicator device is delayed with respect to the end of the injection, which allows the injected product to diffuse into the injection site during this delay period.
    [0036] Figure 21 illustrates a schematic perspective exploded view of this retarder system according to the third embodiment. This comprises the upper body 1c, a retarding spring 18, preferably in the form of a spiral spring, the reservoir 16 'containing a suitable fluid, the shearing member 19 "disposed in said reservoir 16', A locking key 20, the piston rod 5 and the intermediate body 1. In the example shown, the reservoir 16 'also forms a visual indication element of the indicating device. 160 'display suitable to indicate the end of use of the autoinjector in one or more windows of the body 30 1, including the upper body 1c.In the example shown in Figures 20 to 23, the body 1 has three windows 11 which show the progress of the actuation of the retarder system, FIG. 21 illustrates this marking 160 made on the external surface of said reservoir 16. The spiral spring 18 is fixed on the one hand to the rps higher 1 c and secondly to the tank 16 ', as visible in particular in Figure 23a.
    [0037] Alternatively, the spiral spring could be attached to another part of the body 1, for example the intermediate body 1b, or to any element attached to said body 1. Alternatively, said spiral spring could be attached to the body shear 19 ", in which case it is the tank 16 'which would be fixed in rotation relative to the body 1. In this variant, this shifting member movable in rotation 10 could form the indicator element of the visual indicator device, sound and The locking key 20 comprises a head 21 adapted to cooperate with the retarding system, a longitudinal rod 22, and a tip 23 adapted to cooperate with the piston rod 5.
    [0038] In the position before the release of the self-timer system, the head 21 of the locking key 20 is in the locking position in which it cooperates with a corresponding profile 12 of the intermediate body 1b and with a corresponding profile 161 of the tank 16 ', so that it is locked in rotation by said key. When the piston rod 5 arrives towards its position 20 of end of injection, it will cooperate with the tip 23 of the locking key 20, and thus pull said key axially downwards. As a result, the head 21 of said locking key 20 extends axially from said profile 161 of the reservoir 16 ', so that said reservoir 16' is no longer locked in rotation by said key 20. Advantageously, said profile 161 of the reservoir is formed on an inner sleeve 162 of the tank 16 ', disposed within said shear member 19 ", as can be seen in particular in FIG.22. is locked by said locking key 20, the delay system is thus also blocked.
    [0039] When the self-timer system is triggered, the spring 18 biases the tank 16 'in rotation. The latter undergoes a braking torque due to the shearing of the fluid contained between the wall of the tank 16 'and the shearing member 19 ".The rotation of the tank 16' is thus retarded by said fluid. the reservoir 16 'has at least one flexible tab 166, visible in FIG. 23a, the end of which generates a noise during the entire rotation of said reservoir 16', for example on appropriate profiles 106 of the upper body 1c, and thus providing an audible indication of the operation of the self-timer system: when the noise stops, the operation of the self-timer system and that of the indicator device are terminated, and the user can remove the autoinjector from the injection site. At the same time, it is also possible to provide an additional braking of the rotation 16. Alternatively, a plurality of flexible lugs 166, for example two, may be provided in the third embodiment described above. The fluid used in the retarder system may be of any suitable type, for example a grease. A complete phase of actuation of the autoinjector will be described below, which applies to the three embodiments described above. When the user wants to use the autoinjector, he takes the device, for example at the body 1 and he presses the actuator sleeve 10, which at rest, in its first projected position, projects out of the lower body 1, against the part of the body where he wants to perform the injection. The pressure exerted by the user on the actuator sleeve 10 causes the latter to slide towards the inside of the body 1, which exposes the needle and therefore its stitching due to the pressure exerted by the user on the pressure of the needle. 'autoinjector. When the actuator sleeve 10 reaches its actuating position, which is its end position inside the body 1, it triggers the injection phase. It can be seen that the piston rod 5 slides inside the syringe A by pushing the piston P thereof under the effect of the injection spring 8. The product is therefore dispensed. At the end of the injection, the indicating device is triggered, and the delaying system acts so that the indicating device will be actuated completely only after a predetermined delay time, generating a continuous noise between the end of injection and the end of actuation of the indicator device. After indicating the end of use, when the user can withdraw the autoinjector from the injection site, the actuator sleeve 10 is again moved out of the body 1 to the end of use position, which is its second projected position, under the effect of the spring of the actuator sleeve, with a locking of said actuator sleeve 10, which guarantees absolute safety for the user and avoids any risk of injury with the needle after use of the device.
    [0040] It should be noted that the first and second projected positions of the actuator sleeve, which in the example shown are different positions, could possibly be identical. The present invention is applicable to devices used in particular for the treatment of autoimmune diseases, for example of the type rheumatoid arthritis, multiple sclerosis, Crohn's disease, for cancer treatments, for antiviral treatments, for example Hepatitis type, for treatments against diabetes, for treatments against anemia or for treatment of seizures, for example in case of anaphylactic shock.
    [0041] Although the present invention has been described with reference to several advantageous embodiments, it is understood that these are not limiting. In particular, the actuator sleeve and / or the injection lock and / or the delay device and / or the indicator device may be made differently. Stitching of the needle and / or retraction of the needle after injection could be controlled by one or more button (s). Other modifications are also possible for those skilled in the art without departing from the scope of the present invention as defined by the appended claims.
    权利要求:
    Claims (32)
    [0001]
    REVENDICATIONS1. Autoinjector comprising: - a body (1) receiving a reservoir (S), said reservoir (S) containing fluid and comprising a piston (P), such as a pre-filled syringe, - a piston rod (5) adapted to cooperate with the piston (P) of said reservoir (S), said piston rod (5) being displaceable by an injection spring (8) between a loaded position and an injection position in which said piston rod ( 5) has moved the piston (P) of the tank (S) to inject the fluid in an injection site, - an indicating device to indicate to the user that it can remove said autoinjector said injection site, characterized in that said autoinjector comprises a delaying system for delaying the end of actuation of said indicator device with respect to the end of the injection, said indicator device generating a noise during its actuation, said noise being generated until the end of actuation of said indicative device ator.
    [0002]
    An autoinjector according to claim 1, wherein said indicating device and / or said delaying system comprises a rotatable member (19; 19 '; 16') adapted to cooperate with said body (1) for generating said noise.
    [0003]
    An autoinjector according to claim 1 or 2, wherein said indicating device comprises a hood (1000), the body (1), an indicator strip (160), an indicator spring (18), a driving wheel (19), a winding wheel (17a) and a unwinding wheel (17b).
    [0004]
    4. autoinjector according to claim 3, wherein said indicator spring (18) is formed as a spiral spring fixed on the one hand to said drive wheel (19) and on the other hand to said body (1000). . 3036967 25
    [0005]
    An autoinjector according to claim 3 or 4, wherein said driving wheel (19) comprises a gear (195) which cooperates with a gear (175) of the winding wheel (17a), so that a rotation said driving wheel (19) causes a rotation of said winding wheel (17a), causing said indicator band (160) to wind on said winding wheel (17a).
    [0006]
    6. autoinjector according to any one of claims 3 to 5, 10 wherein said locking key (20) comprises a head (21), a longitudinal rod (22), and tip (23) adapted to cooperate with the piston rod (5).
    [0007]
    7. An autoinjector according to claim 6, wherein, before triggering the indicator device, the head (21) of the locking key (20) is in the locking position in which it cooperates with a corresponding profile (190) of the driving wheel (19), so that said drive wheel (19) is locked in rotation relative to said body (1) and said cover (1000) by said locking key (20). 20
    [0008]
    8. An autoinjector according to claim 7, wherein when the piston rod (5) arrives to its end of injection position, it cooperates with the end piece (23) of the locking key (20) to pull said key locking member (20) axially downward from its locking position, so that said driving wheel (19) is no longer locked in rotation by said locking key (20).
    [0009]
    9. autoinjector according to any one of claims 3 to 8, wherein said body (1) comprises at least one flexible lug (1100) adapted to cooperate with said drive wheel (19) to generate a noise during the rotation of said driving wheel (19). 3036967 26
    [0010]
    10. An autoinjector according to claim 1 or 2, wherein said retarder system comprises an epicyclic gear train having at least one, advantageously two, stage (s), said epicyclic gear train having a retarding spring (18), at least one sun gear (16a). , 16b), each having at least one satellite (17a ', 17b'), a trigger (19 '), and a locking key (20) for locking said trigger (19') in rotation until the end of injection.
    [0011]
    An autoinjector according to claim 10, wherein said retarding spring (18) is in the form of a spiral spring secured on the one hand to a sun gear (16a, 16b) or to the trigger (19 ') and on the other hand to the body (1).
    [0012]
    12. An autoinjector according to claim 10 or 11, wherein each satellite (17a ', 17b') of a sun gear (16a, 16b) cooperates on the one hand with said body (1) and on the other hand is with another sun gear (16b, 16a), or with said trigger (19 ').
    [0013]
    An autoinjector according to claim 12, wherein said body (1) has a gear (155) on its lateral inner surface, said gear (155) cooperating with at least one satellite (17a ', 17b').
    [0014]
    An autoinjector according to claim 12 or 13, wherein said trigger (19 ') has a central axis (192) provided with a gear cooperating with at least one satellite (17a', 17b ').
    [0015]
    15. autoinjector according to any one of claims 10 to 14, wherein said epicyclic train comprises two planetaries (16a, 16b), each having three satellites (17a ', 17b'). 30
    [0016]
    16. An autoinjector according to any one of claims 10 to 15, wherein said locking key (20) comprises a head (21), a longitudinal rod (22), and tip (23) adapted to cooperate with the piston rod (5).
    [0017]
    17. An autoinjector according to claim 16, wherein, before triggering the self-timer system, the head (21) of the locking key (20) is in the locking position in which it cooperates with a corresponding profile (12) of the body (1) and with a corresponding profile (190 ') of the release (19'), so that said trigger (19 ') is locked in rotation relative to said body (1) by said locking key (20).
    [0018]
    18. An autoinjector according to claim 17, wherein when the piston rod (5) arrives towards its end of injection position, it cooperates with the end piece (23) of the locking key (20) to pull said key latch (20) axially downward from its locking position, so that said trigger (19 ') is no longer locked in rotation by said locking key (20).
    [0019]
    19. An autoinjector according to any one of claims 10 to 18, wherein said trigger (19 ') comprises at least one flexible tab (195a, 195b, 195c) adapted to cooperate with said body (1) to generate a noise during rotation of said trigger (19 ').
    [0020]
    An autoinjector according to claim 1 or 2, wherein said retarder system comprises a reservoir (16 '), a shear member (19 ") disposed in said reservoir (16') and a fluid disposed in said reservoir (16 '). ') around said shear member (19 "), one of said tank (16') and said shear member (19") being rotatably mounted in said body (1) and the other of said tank (16 ') ) and said shear member (19 ") being fixed in rotation, the rotation of one with respect to the other being braked by shearing said fluid contained in said reservoir (16 '). 3036967 28
    [0021]
    An autoinjector according to claim 20, wherein said reservoir (16 ') is rotatably mounted in said body (1) and said shear member (19 ") is rotationally fixed.
    [0022]
    An autoinjector according to claim 20 or 21, wherein said reservoir (16 ') has projections (165) on its inner surface and said shear member (19 ") has projections (195) on its outer surface, said projections (165, 195) generating restrictions on fluid flow.
    [0023]
    An autoinjector according to any one of claims 20 to 22, wherein said retarder system comprises said reservoir (16 ') containing said fluid, said shear member (19 "), a retarder spring (18), a key locking member (20) and said piston rod (5).
    [0024]
    24. An autoinjector according to claim 23, wherein said locking key (20) comprises a head (21), a longitudinal rod (22) and endpiece (23) adapted to cooperate with the piston rod (5). 20
    [0025]
    An autoinjector according to claim 24, wherein, before the release system is triggered, the head (21) of the locking key (20) is in the locking position in which it cooperates with a corresponding profile (12) of the body ( 1) and with a corresponding profile (161) of said reservoir (16 '), so that said reservoir (16') is locked in rotation with respect to said body (1) by said locking key (20).
    [0026]
    An autoinjector according to claim 25, wherein when the piston rod (5) reaches its end-of-injection position, it cooperates with the end-piece (23) of the locking key (20) to pull said locking key (20) axially downward from its locking position, so that said reservoir (16 ') is then no longer locked in rotation by said locking key (20).
    [0027]
    An autoinjector according to any one of claims 23 to 26, wherein said retarding spring (18) is in the form of a spiral spring attached on the one hand to said reservoir (16 ') or to said shear (19 ") and on the other hand to said body (1).
    [0028]
    An autoinjector according to claim 27, wherein said reservoir (16 ') has at least one flexible lug (166) cooperating with a plurality of profiles (106) of said body (1) to generate a continuous noise during operation. actuating said delay system.
    [0029]
    An autoinjector according to any one of the preceding claims, wherein said autoinjector comprises an actuator sleeve (10) having a contact end (101) intended to come into contact with the body of the user, said actuator sleeve ( 10) extending at least partially inside said body (1) and being displaceable relative to said body (1) between projected positions, in which said actuator sleeve (10) at least partially protrudes from said body ( 1), and an actuating position, wherein said actuator sleeve (10) is axially displaced inwardly of said body (1), said actuator sleeve (10) being in a first projected position prior to actuation of the autoinjector and 25 in a second projected position after actuating the autoinjector.
    [0030]
    An autoinjector according to any one of the preceding claims, wherein said reservoir (S) comprises a needle (A) through which said fluid product is injected into said injection site. 3036967 30
    [0031]
    An autoinjector according to claim 2, wherein one of said rotatable member (19; 19 '; 16') and said body (1) comprises at least one flexible tab (1100; 195a, 195b, 195c; 166) cooperating with adapted profiles formed on the other of said rotating movable member (19; 19 '; 16') and said body (1) for generating said noise.
    [0032]
    32. An autoinjector according to claim 31, wherein the shapes and / or dimensions of said at least one flexible tab and / or said adapted profiles are variable, to generate a variable noise.
    类似技术:
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    FR3003470A1|2014-09-26|autoinjector
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    同族专利:
    公开号 | 公开日
    CN107708771B|2020-09-15|
    WO2016193622A1|2016-12-08|
    FR3036967B1|2021-10-01|
    US10500337B2|2019-12-10|
    EP3302644B1|2021-01-27|
    CN107708771A|2018-02-16|
    EP3302644A1|2018-04-11|
    JP6762965B2|2020-09-30|
    JP2018516699A|2018-06-28|
    US20180207363A1|2018-07-26|
    引用文献:
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    WO2011109205A2|2010-03-01|2011-09-09|Eli Lilly And Company|Automatic injection device with delay mechanism including dual functioning biasing member|
    WO2012022810A2|2010-08-19|2012-02-23|Novo Nordisk A/S|Medical injection device|
    WO2013078200A1|2011-11-22|2013-05-30|Becton, Dickinson And Company|Drug delivery system with a delay mechanism|
    WO2013175140A1|2012-05-25|2013-11-28|Aptar France Sas|Autoinjector|
    WO2013175144A1|2012-05-25|2013-11-28|Aptar France Sas|Autoinjector|
    FR2899482A1|2006-04-11|2007-10-12|Becton Dickinson France Soc Pa|Automatic medicament/product injection device for patient, has safety shield coupled to housing, and provided in active state at end of needle insertion step before which product/medicament injection step is not started|
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    US9931467B2|2012-05-25|2018-04-03|Aptar France Sas|Autoinjector|
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    FR3019749B1|2014-04-11|2016-05-13|Aptar France Sas|autoinjector|EP3319664B1|2015-07-10|2020-12-16|ALK-Abelló A/S|An injector comprising a safety pin|
    EP3348294A1|2017-01-13|2018-07-18|Carebay Europe Ltd.|Medicament delivery device|
    FR3086176A1|2018-09-20|2020-03-27|Aptar France Sas|AUTOINJECTOR.|
    EP3669911A1|2018-12-18|2020-06-24|SHL Medical AG|Medicament delivery device|
    US20220062556A1|2019-01-16|2022-03-03|Daicel Corporation|Needleless injector|
    法律状态:
    2016-06-29| PLFP| Fee payment|Year of fee payment: 2 |
    2016-12-09| PLSC| Search report ready|Effective date: 20161209 |
    2017-06-27| PLFP| Fee payment|Year of fee payment: 3 |
    2018-06-27| PLFP| Fee payment|Year of fee payment: 4 |
    2020-06-25| PLFP| Fee payment|Year of fee payment: 6 |
    2021-06-28| PLFP| Fee payment|Year of fee payment: 7 |
    优先权:
    申请号 | 申请日 | 专利标题
    FR1555166A|FR3036967B1|2015-06-05|2015-06-05|AUTOINJECTOR|FR1555166A| FR3036967B1|2015-06-05|2015-06-05|AUTOINJECTOR|
    CN201680032426.2A| CN107708771B|2015-06-05|2016-06-02|Automatic injector|
    PCT/FR2016/051312| WO2016193622A1|2015-06-05|2016-06-02|Auto-injector|
    EP16736901.6A| EP3302644B1|2015-06-05|2016-06-02|Auto-injector|
    JP2017563257A| JP6762965B2|2015-06-05|2016-06-02|Self-syringe|
    US15/575,881| US10500337B2|2015-06-05|2016-06-02|Auto-injector|
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